Recently, I rediscovered Unison. I was also pleased to learn that the tool is available on macOS as a native app. It works well, except one minor limitation: you can create profiles, but you cannot delete or edit them in the app. As I'm not overly familiar with macOS, it took me a while to figure that one out.
Turned out that all Unison data, including .prf profile files, are stored in /Users/$USER/Library/Application Support/Unison (where $USER is the actual user name). Deleting a profile is matter of moving it to Trash. And you can edit profiles using a text editor.
While at it, I also learned how to exclude those pesky .DS_Store files from sync by adding the following instruction to the profile:
ignore = Name .DS_Store